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The first season consists of 22 episodes that aired between November 2004 and May 2005. Each episode typically follows a "case of the week" format while slowly building the backstory of House, his oncology best friend Dr. James Wilson, and his boss Dr. Lisa Cuddy. Comprehensive Episode List
Damned If You DoDuring Christmas, a nun with swollen hands and a rash leads House to investigate her past and the ethics of faith.
Babies & BathwaterThe conflict with Vogler reaches a boiling point during the case of a pregnant woman with lung cancer.
FidelityA woman with African Sleeping Sickness forces House to confront the reality of her hidden extramarital affair.
PaternityA teenage boy experiences night terrors and hallucinations. The team discovers a rare form of measles in the brain caused by his mother not being vaccinated.
Pilot (Everybody Lies)The series opener introduces 29-year-old kindergarten teacher Rebecca Adler, who suffers from mysterious seizures. House deduces she has neurocysticercosis from undercooked pork.
CursedA young boy who thinks he’s cursed by a Ouija board actually has anthrax, leading to a hunt for the source.
Role ModelVogler pressures House to give a speech for a new drug in exchange for keeping his team employed.
HeavyA ten-year-old girl with a weight problem suffers a heart attack, leading to a diagnosis of Cushing's Syndrome.
Mob RulesA mob informant collapses before testifying. House must determine if he is faking or truly dying of an obscure condition.